Fig. 2: Four genetic maps of the plasma proteome and metabolome in participants with African and European ancestry.
a Map of 954 AFR pQTLs. The X-axis is the chromosome position of the pQTL; the Y-axis is the chromosome of the gene encoding the corresponding protein. The color code is magenta as cis-pQTLs and blue as trans-pQTLs. The point size represents the negative-log10-p value, the scales are from 0 to 200. P values are unadjusted, two-sided, and determined via linear regression analysis. The p value threshold is after multiple testing correction. The value threshold for cis-pQTL is 5 × 10−8 and for trans-pQTL is 1.49 × 10-10 (5 × 10-8/336). b Map of 2848 EUR pQTLs. Same X, Y, and color code as panel-A. The point size represents the negative-log10-p value, the scales are from 0 to 750. The p value threshold for cis-pQTL is 5 × 10−8 and for trans-pQTL is 3.40 × 10-11 (5 × 10−8/1472). c Map of 65 AFR mQTLs. The X-axis is the chromosome position of the mQTL; the Y-axis is the metabolite order (based on the super pathway). The color code is red as 01_Amino Acid; orange as 02_Cofactors and Vitamins; yellow as 03_Lipid; limegreen as 04_Energy; cyan as 05_Carbohydrate; blue as 06_Nuleotide; purple as 07_Peptide; deepplink1 as 08_Xenobiotics; brown as 09_Partially Characterized Molecules; black as 10_Unknown categories. P values are unadjusted, two-sided, and determined via linear regression analysis. The p value threshold is after multiple testing correction, and it is 1.78 × 10−10 (5 × 10−8/281). d Map of 490 EUR mQTLs. Same X, Y, and color code as panel-C. The p value threshold is after multiple testing correction and it is 6.53 × 10−11 (5 × 10−8/766).
