Fig. 3: BAT transplantation increases 12,13-diHOME and injection with 12,13-diHOME improves cardiac function. | Nature Communications

Fig. 3: BAT transplantation increases 12,13-diHOME and injection with 12,13-diHOME improves cardiac function.

From: 12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII

Fig. 3

a Volcano plot of lipidomics; n = 16 (sham), n = 15 (+BAT), and b quantification of 12,13-diHOME after BAT transplantation. Acute injection of 12,13-diHOME increases c systolic and d diastolic function in aged male mice. n = 4 (9,10-diHOME) and 5 (12,13-diHOME). Data are expressed as mean ± SEM. Volcano plot shows the log2 fold change versus –log10 (p) value from two-sided Student’s t tests. False discovery rate (FDR) correction was applied, with significance threshold set at FDR < 0.05 (a). Two-tailed P values by unpaired Student’s ttest (b–d). Bar colors: white (9,10-diHOME), blue (12,13-diHOME) (b–d).

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