Fig. 9: F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIbα interaction in platelets. | Nature Communications

Fig. 9: F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIbα interaction in platelets.

From: F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIbα interaction in platelets

Fig. 9: F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIbα interaction in platelets.The alternative text for this image may have been generated using AI.

GPIbα interaction with VWF under high shear stress induces F-actin and MICAL1 recruitment in the GPIb-IX-V complex, which limits F-actin associated within the GPIb-IX-V complex. This process both facilitates receptor translocation to lipid rafts, which strengthens its interaction with VWF and promotes the retraction of platelet membrane tethers, resulting in increased platelet adhesion. Ultimately, GPIbα mechanotransduction activates platelets, increasing their resistance to deformation and enabling stable platelet adhesion and thrombus stability. Created in BioRender. Solarz, J. (2025) https://BioRender.com/hfvgvsz.

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