Fig. 4: LAVA local genetic correlation (r_{g, local}) results for BMI and testosterone.

While the LDSC- r_{g, global} estimate for BMI is close to one, many loci have r_{g, local}s that strongly and significantly diverge from one (e.g., locus 1727). In contrast, the testosterone LDSC- r_{g, global} estimate is close to zero, while some loci are strongly negative and others positive (e.g., locus 963 and 2020). Similar plots for all other traits can be found in our Zenodo repository (https://doi.org/10.5281/zenodo.15213372). A Bonferroni-corrected significance threshold of p < 0.05/11259 = 4.44e-06 was used for r_{g, local}s.