Table 1 Susceptibility of various fungal species isolates to coniotin A and B compared with established clinical antifungal agents

From: Coniontins, lipopetaibiotics active against Candida auris identified from a microbial natural product fractionation library

Organism

MIC (μg/mL)

Coniotin A

Amphotericin B

Caspofungin

Fluconazole

Coniotin B

C. neoformans H99

4

0.5

32

8

16

C. auris CBS10913

4

1

0.5

8

ND

C. auris CBS12766

8

4

64

>64

16

C. auris CBS12775

8

4

64

>64

ND

C. auris CBS12776

8

4

64

>64

16

C. parapsilosis ATCC22019FluR

16

1

2

2

ND

C. tropicalis ATCC200956AmBR

4

8

0.25

>64

ND

N. glabratusFluR

4

1

0.5

4–8

ND

C. albicans ATCC 90028

4

0.5

0.25

8

16

C. albicans ATCC 200955AmBR

16

2

0.5

>64

ND

S. cerevisiae BY4741

4

0.25

0.125

4

ND

S. cerevisiae BY4742

4

0.25

0.125

8

ND

A. fumigatus Af293

4

0.5

64

>64

ND

A. fumigatus 1478FluR

4

0.5

64

>64

ND

Human erythrocytes

>256

8

128

ND

128

  1. Minimal inhibitory concentrations (MICs) of coniotin A and B were determined via broth microdilution against various fungal isolates, compared to established clinical agents.
  2. AmBR amphotericin B-resistant strains, FluR fluconazole-resistant isolates. Compound concentrations are presented in μg/mL, ND not determined.
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