Fig. 6: Patient-reported outcomes.

A Evolution of EQ-5D-5L score over time. B Physical fatigue (per FA-12) over time. C QLQ-C30 GHS/HRQoL over time. D Time to first 10-point deterioration in GHS/HRQoL. CI confidence interval, GHS global health status, HRQoL health-related quality of life.