Table 1 Virus dissemination after rectal challenge

From: Efficacy of modified-vaccinia Ankara vaccine as pre- and post-exposure prophylaxis against monkeypox sexual transmission in non-human primate model

 

Viral DNA (copies/mg)

Infectious particles (pfu/g)

 

MF11

MF12

MF11

MF12

Kidney (right)

<LLOD

<LLOD

NA

NA

Rectum

1.97E + 08

6.54E + 09

7.56E + 04

8.52E + 04

Duodenum

2.00E + 08

6.42E + 05

1.84E + 04

<LLOD

Descendant colon

<LLOD

2.64E + 07

3.60E + 01

3.20E + 01

Liver

<LLOD

<LLOD

NA

NA

Spleen

<LLOD

2.65E + 05

<LLOD

3.30E + 01

Iliac lymph node

<LLOD

<LLOD

NA

NA

Axillary lymph node

<LLOD

<LLOD

<LLOD

9.09E + 01

Inguinal lymph node

<LLOD

<LLOD

<LLOD

9.09E + 01

Paracolic lymph node

4.99E + 09

8.30E + 07

1.92E + 03

2.33E + 03

Mesenteric lymph node

1.00E + 05

3.43E + 08

<LLOD

2.94E + 01

  1. Two NHPs were euthanized on day 11 post-challenge for MPXV dissemination evaluation. MPXV viral load was evaluated in the urinary tract, digestive tract, and lymphatic system. In the left-hand columns, viral DNA concentration is expressed as copies/mg of organ. Organs were considered positive when viral DNA was detected by qPCR (CT < 38, equivalent to 90,000 copies/mL). No viral DNA detected (<LLOD). In the right-hand columns, virus infectivity is expressed as pfu/g of organ. Organs were considered positive when a least one single plaque-forming unit was detected. Virus infectivity < LLOD.
  2. NA not tested.
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