Fig. 5: RNA labelling in the liver after injury.
From: SLAMseq reveals potential transfer of RNA from liver to kidney in the mouse
a T > C conversion rates in mRNA SLAMseq data. Rates were higher in the RNA labelling groups than the Cre -ve control group (p < 2–16 by Kruskal-Wallis test and post hoc Wilcoxon signed rank tests). b Labelled transcripts in health. Transcripts in mRNA SLAMseq data that were deemed to be labelled by the beta-binomial test are depicted in red. c Labelled transcripts after injury. d T > C conversion rates in smallRNA. Rates were higher in the RNA labelling groups than the Cre -ve control group (p < 2–16 by Kruskal-Wallis test and post hoc Wilcoxon signed rank tests). e T > C conversion rates in small RNA, stratified by RNA biotype. f Labelling of small RNA in healthy liver. g Labelling of small RNA in the liver after paracetamol. h T > C conversion rates in the known hepatocyte-enriched miRNA, miR-122, and the known endothelial-enriched miRNA, miR-23a. Data from male mice; n = 6 (labelled after paracetamol), n = 6 (labelled in health), n = 5 (Cre-negative control), n = 3 (4TU-negative control). Source data are provided as a Source Data file.
