Fig. 7: Grid maps change locally near the home cage.
a In the experiment by Sanguinetti-Scheck and Brecht49, grid cells are recorded before and after the introduction of a home cage. Here, two example normalized grid fields are plotted for two different home cage locations (north or middle). b Sliding window spatial correlation map averaged across all cells is plotted for two different locations of the home cage. The impact of introducing the home cage is mostly limited to locations near the cage. c The peak normalized firing map for all cells is plotted as a function of the distance between each cell’s peak location and the center of the home cage. The local impact of the home cage on grid maps is also evident in the peak normalized rate map. The mean and standard error of the mean are plotted. d The spatial average of the peak normalized rates is illustrated for both the open field and the home center condition, with the difference also displayed. The same effect is apparent in this comparison. e Sliding window spatial correlation map averaged across all cells is plotted for another experimental condition in which a plain box is introduced with the same size as the home cage. The effect of the plain box is very similar to that of the home cage, revealing that changes in grid cells are driven by the geometry rather than the home valence. f–j Simulation of experimental results in (a–e) by the model. The simulation results in (f–j) were repeated 50 times with different randomization seeds, and the average has been plotted. Error bars in (h) indicate the standard error of the mean across simulations. See also Supplementary Fig. 3. Data in (a–e) are adapted from Sanguinetti-Scheck and Brecht49 under a CC BY license: https://creativecommons.org/licenses/by/4.0/.
