Fig. 6: Cell-cell interactions in the human cerebral cortex.
From: Charting the spatial transcriptome of the human cerebral cortex at single-cell resolution
a Spatial slide of major subclasses of Glutamatergic neuron (EXC), GABAergic neurons (INH), and non-neuronal cells in 4 lobes (left); and zoomed-in view of the boxed region show multiple somatic contact forms of cell-cell interactions at spatial maps (right). Colored shapes are cell nuclei segmentations. The slide size is 1x1cm, and the subclasses are displayed using the cell bin. b Enrichment map of pairwise soma contact or proximity for subclasses of cells in the human cortex. The color indicates the observed frequency of soma contact or proximity. c Heatmap showing the laminar arrangement of soma contact or proximity interaction patterns (1v1) in the four brain lobes. d, e Heatmap showing the distribution of frequent interaction patterns across cortical regions. f Line chart and heatmap showing the distribution of the somatic contact forms between OLIGO/OPC and various neuronal subclasses in 14 cortical regions. Error bars are provided in the Source Data. g Enrichment of ligand-receptor pairs in contacting microglia/astrocytes and neuronal subclasses. h Line chart and heatmap showing the distribution of the somatic contact forms between astrocyte and various neuronal subclasses in 14 cortical regions. Error bars are provided in the Source Data. i Line chart and heatmap showing the distribution of the somatic contact forms between microglia and various neuronal subclasses in 14 cortical regions. Error bars are provided in the Source Data. j Heatmap showing the distribution of pairing contact microglia/astrocytes and INH/EXC in 14 human cortices.
