Fig. 5: Conserved RNA domains similar to bacterial guanidine-I riboswitch aptamers are associated with numerous vertebrate genes relevant to Ca2+ signaling and neuromuscular function. | Nature Communications

Fig. 5: Conserved RNA domains similar to bacterial guanidine-I riboswitch aptamers are associated with numerous vertebrate genes relevant to Ca2+ signaling and neuromuscular function.

From: Guanidine aptamers are present in vertebrate RNAs associated with calcium signaling and neuromuscular function

Fig. 5

a Consensus sequence and structural model for bacterial guanidine-I riboswitch aptamers2 used as the basis for the search for similar RNAs in vertebrates. Annotations are as described for Fig. 1. b Pie chart depicting genes associated with RNAs similar to bacterial guanidine-I aptamers. For the most commonly associated genes, the number of hits identified by an initial comparative sequence analysis run using an e-value cutoff of 10 are given in parentheses. c Consensus sequence and structural model for the top 51 hits identified in vertebrate ITPR1 mRNAs (Supplementary Fig. 14) using a comparative sequence analysis search pipeline (see Materials and Methods). Boxed regions identify sequences and structural features that are similar between the bacterial and vertebrate models.

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