Fig. 1: Cryo-EM structures of human TauT complexes.
From: Molecular basis of human taurine transporter uptake and inhibition
a Cryo-EM map of TauTTau complex, captured in the occluded conformation. The TauT density is colored in a rainbow pattern and contoured at 5.6 σ by ChimeraX. The dimensions of the model are labeled as indicated. b Overall structure of TauTTau in cartoon representation. TM1, TM3, TM6, TM8 and TM12 are labeled. The taurine, sodium (Na+), and chloride ion (Cl–) are depicted as cyan, purple and green spheres, respectively. c Densities of substrate taurine and substrate analogs in the structures of TauT complexes. The densities are contoured at 4.5 σ by ChimeraX. d Surface representation of the electrostatic potential of the binding cavity. Red and blue indicate negatively and positively charged regions, respectively. The structure is overlaid in rainbow ribbon and taurine is shown in cyan sphere representation.
