Fig. 1: Cortex enlargement induced by Cep83 and Flrt1/Flrt3 deletion.
From: Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration
a Quantification of cortical areas. Data are represented as a box plot, with median (center line), interquartile range (box) and minimum and maximum values (whiskers); Flrt1 −/−Flrt3 lx/+, n = 9 brains; Emx1-Cre;Flrt1/3 dKO, n = 13 brains from 7 litters, two-tailed t-test with Welch correction. b E17.5 Flrt1 −/−Flrt3 lx/+ and Emx1-Cre;Flrt1/3 dKO brain sections labeled with Satb2 (green), Ctip2 (red), and DAPI (blue). Area in dashed rectangle is shown with higher magnification on the right. Scale bars, 100 μm. c Quantification of E17.5 cortical areas. Cep83 lx/lx, n = 14 brains; Cep83 cKO, n = 16 brains from 4 litters. Data are represented as a box plot (as above). d Representative whole-mount images of E17.5 CTL, Cep83 dKO, and Cep83 tKO brains. Dashed areas were measured to obtain quantification in (e). Scale bar, 1 mm. e Quantification of cortical areas. CTL, n = 11 brains; Cep83 dKO, n = 13 brains; Cep83 tKO n = 19 brains from 10 litters. Data are represented as a box plot (as above).
