Fig. 7: Antibody blockade of Basigin in aging mice reinvigorates skeletal remodeling improving bone mass. | Nature Communications

Fig. 7: Antibody blockade of Basigin in aging mice reinvigorates skeletal remodeling improving bone mass.

From: Basigin links altered skeletal stem cell lineage dynamics with glucocorticoid-induced bone loss and impaired angiogenesis

Fig. 7: Antibody blockade of Basigin in aging mice reinvigorates skeletal remodeling improving bone mass.The alternative text for this image may have been generated using AI.

a IHC of Basigin expression in tibias of 24-month-old mice. Right: Histology-based quantification Basigin-expression cells per analyzed area. n = 3 biologically independent mice per sex and group. b H&E staining of proximal tibia regions below the growth plate. Right: Histology-based quantification of tibial trabecular BV/TV. n = 12 biologically independent female mice per group. n = 9 biologically independent male mice per group. c DEXA bone mineral density (BMD) measurements of vertebral L5 at treatment starting day-0 and at day-14 of treatment. d Micro-CT measurement of vertebral L5 BV/TV at 4 weeks of treatment. n = 5 biologically independent mice per sex and group. e Representative Alizarin Red S staining of in vitro osteogenesis. Cells from n = 5 independent mice per group. f TRAP quantification in tibia sections of experimental groups. N.Oc/BS: number of osteoclasts per bone surface. Analysis of n = 4 biologically independent female mice per group. n = 3 biologically independent male mice per group. g Graphical summary of experimental findings. Created in BioRender. Ambrosi, T. (2025) https://BioRender.com/03daips. All data shown as mean ± SEM. Statistical testing between IgG control and other group by two-sided unpaired Student’s t-test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Scale bars, 50 µm.

Back to article page