Table 3 Short- and long-term contributions of K5 engineering in FIX-HSA fusion proteins

From: Tailored collagen binding of albumin-fused hyperactive coagulation factor IX dictates in vivo distribution and functional properties

K5 substitution

Col4 binding

Short-term impact on plasma level (1 h)

Long-term impact (>24 h)

Plasma half-life

Functional half-life

K5A

–

++++

–

–

K5R

++++

++

++++

++++

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