Fig. 8: Conceptual diagram illustrating the potential interaction between cholecystectomy and colon carcinoma.
From: Cholecystectomy-related gut microbiota dysbiosis exacerbates colorectal tumorigenesis
Cholecystectomy can induce gut microbiota disorder, characterized by a significant decrease in the abundance of B. breve and an increase in the abundance of R. gnavus. The reduction in B. breve elevates the level of TUDCA via its BSH activity. Meanwhile, the augmented R. gnavus can promote the formation of TUDCA through its 7β-HSDH activity. TUDCA may ultimately lead to colon carcinoma by disrupting the interaction between FXR and β-catenin, which could further increase the binding of β-catenin and TCF4, thereby promoting MYC expression and facilitating colorectal tumorigenesis. OCA treatment may ultimately prevent colon carcinoma through FXR activation. The schematic was created using Adobe Illustrator 2024 (v28.7.0). B. breve, Bifidobacterium breve, R. gnavus, Ruminococcus gnavus; TUDCA tauroursodeoxycholic acid, 7β-HSDH 7β-hydroxysteroid dehydrogenase, BSH bile salt hydrolase, FXR farnesoid X receptor, TCF4 transcription factor 4, OCA obeticholic acid.
