Fig. 2: LT patient samples associated with IRI. | Nature Communications

Fig. 2: LT patient samples associated with IRI.

From: Biosilica nanoparticulate scavengers for the therapy of hepatic ischemia–reperfusion injury in preclinical models

Fig. 2: LT patient samples associated with IRI.The alternative text for this image may have been generated using AI.

Hematoxylin and eosin (HE, a, with the SUZUKI score), dihydroethidium (DHE, b) and transferase dUTP nick end labeling (Tunel, c) staining images on the liver tissues of LT patients; blue: cell nucleus stained with 4,6-diamidino-2-phenylindole (DAPI), red: ROS, green: apoptotic cells, n = 12 biological replicates. d Immunohistochemical (IHC) images on the liver tissues of LT patients, n = 12 biological replicates. e DAPI (as a cell nucleus marker, blue), CD31 (as an endothelial marker, pink), myeloperoxidase (MPO, as a neutrophil marker, yellow), CD68 (as a total macrophages marker, white), CD86 (as a M1 macrophages marker, green) and CD206 (as a M2 macrophages marker, orange) multiplex immunofluorescence (IF) images on liver tissues of LT patients, n = 6 biological replicates. Serum cfDNA, biochemical indexes (f) and serum cytokine levels (g) in healthy volunteers (HV, n = 20 biological replicates) and LT patients (n = 20 biological replicates) at different times after surgery. h Linear regression curves illustrating the correlation between serum cfDNA to biochemical indexes and cytokine levels in LT patients. Data presented as the mean ± SD. *P < 0.05, **P < 0.01 and ***P < 0.001 by one-way ANOVA. Source data are provided as a Source Data file.

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