Fig. 2: Local comparison of digital histology images using a single feature.

As an example, glomerular hypertrophy is compared in diabetes and reference tissue. Percentage eosinophilic area between normal and sclerotic glomeruli from diabetic and reference kidney samples. A–D Example glomeruli selected from the feature distribution as indicated. Dots represent individual glomeruli. Sclerosis increases eosinophilic area by reducing open capillary lumens and Bowman’s space. Diabetic kidney disease, in the absence of sclerosis, increases eosinophilic area through hypertrophy and expansion of the mesangium. Scale bar indicates 25 µm. Two-sided unpaired Student’s t test. Data reflect n = 3 independent replicates per group. Source data are provided as a Source Data file.