Fig. 1: Schematic illustration.
From: Restoring mucosal barrier homeostasis by in situ formation of a living-synthetic therapeutic coating
A Preparation of LSTC by in situ forming an EG-BiIII coating hybridized with living LGG on the mucosal surface. B Combination of the barrier-repairing ability of BiIII ions, the immunosuppressive feature of EG, and the microbiota-regulating behavior of LGG enables LSTC to multifacetedly restore mucosal barrier functions. Specifically, LSTC improves barrier integrity by increasing the secretions of tight junctions and mucus, remits mucosal inflammation by suppressing the production of inflammatory cytokines, and maintains normal homeostasis of the microbiota by inhibiting the colonization of pathogens. Created in BioRender.
