Fig. 3: Spatial organization of functional groups and disease-causing genes.

a Ridge plots of differential gene expression across CA1 strata for selected gene sets. Each plot represents the distribution of z-scored log₂ fold changes for all transcripts (left) or proteins (right) annotated to specific biological processes or cellular components (see methods, source data and Supplementary Data 1-2 for detailed annotations). b Candidate heatmaps for z-scored log₂ fold changes of transcripts and proteins associated with processes or cellular components shown in (a). Genes are ordered based on clustering of protein data. White boxes indicate missing values. Asterisks indicate significance in either mRNA or protein dataset as derived from differential expression analysis (s value < 0.01 or p adjusted <0.01, respectively, n = 7; see methods for details on normalization and differential expression). c, d Boxplots of abundances of mRNAs and proteins that have causative roles in disease and showed strata-specific enrichment. ± indicates significant enrichment or depletion in differential expression analysis (s value < 0.01 or p adjusted <0.01, respectively, n = 7; see methods for details on normalization and differential expression). Boxes indicate median (middle line) and interquartile ranges (IQR), with whiskers at 1.5 × IQR. Points represent values for each biological replicate (n = 7). Source data are provided as a source data file.