Fig. 3: Cryo-EM structure of VCP bound to VCPID and adapter protein p47. | Nature Communications

Fig. 3: Cryo-EM structure of VCP bound to VCPID and adapter protein p47.

From: Structural basis of VCP-VCPIP1-p47 ternary complex in Golgi maintenance

Fig. 3

a Domain organization of p47 showing the presence of its major domains: ubiquitin associated (UBA) (red), SEP domain (blue), SHP box (brown), UBX domain (lime green) and the connecting linker (beige). b Low pass filtered (6.0 Å) map of VCP-VCPIP1-p47 ternary complex depicted in top, side and bottom views with a 90° rotation. c Comparison of VCPIP1 UBX and p47 UBX domains. d Zoom in on density for p47 bound to VCP N-domain. e zoom in of interactions formed by p47 UBX domain and VCP N-domain. f zoom in on interactions formed between p47 SHP binding site and linker region and VCP N-domain.

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