Fig. 4: Dehydroxy-perfluoro-tert-butylation of alcohols.

Unless mentioned otherwise, substrate 2 (1.0 equiv), PFtBS (1, 2.0 equiv), CsF (3.0 equiv), KI (0.1 equiv) and NMP (0.1 M) were added to a sealed tube. The mixture was stirred at 0 °C for 24 h. Yields referred to isolated products. ^a1 (4.0 equiv) and CsF (6.0 equiv) were used. ^b(4-(bromomethyl)phenyl)methanol was used as substrate. 1 (3.0 equiv) and CsF (4.0 equiv) was used, KI was not used. ^c1 (2.5 equiv) and KI (0.5 equiv) were used, DMF (0.1 M) instead of NMP (0.1 M), reactions were stirred at 80 °C for 24 h. ^dYields were determined by ¹⁹F NMR with PhOCF₃ as an internal standard.