Fig. 8: NSUN2 promotes RNA turnover at DNA breaks via DICER-dependent degradation of DARTs.
From: NSUN2 facilitates DICER cleavage of DNA damage-associated R-loops to promote repair
Upon DNA damage, NSUN2 is recruited to transcriptionally active break sites, where it methylates DARTs. This modification enhances their processing by DICER, promoting RNA turnover. The NSUN2/DICER interaction facilitates R-loop resolution and ensures the clearance of damage-associated transcripts, a critical step for efficient DNA repair. Together, this synergy between RNA modification and structured RNA processing links transcriptome dynamics to genome stability. Created in BioRender. Gullerova, M. (https://BioRender.com/covu936).
