Fig. 1: Miami plot of sex-stratified genome-wide association study (GWAS) meta-analysis of Major Depressive Disorder (MDD), with female and male meta-analyses shown on the top and bottom, respectively.
From: Sex-stratified genome-wide association meta-analysis of major depressive disorder
The two-sided, unadjusted –log10 p values for GWAS results of each single nucleotide polymorphism (SNP) are shown with positions according to human genome build 37 (GRCh37 assembly). Chromosome 23 is the X chromosome. The darker grey and lighter grey dotted horizontal lines indicate genome-wide significance (P = 5 × 10−8) and nominal significance (P = 1 × 10−6), respectively. SNPs in dark purple indicate the lead independent genome-wide significant SNPs, and any SNPs in linkage disequilibrium with them. Females: 130,471 cases, 159,521 controls. Males: 64,805 cases, 132,185 controls.
