Fig. 3: Manhattan plot of genome-wide genotype-by-sex (GxS) interaction meta-analysis for Major Depressive Disorder (MDD).
From: Sex-stratified genome-wide association meta-analysis of major depressive disorder
The two-sided, unadjusted –log10 p values for GxS results of each single nucleotide polymorphism (SNP) are shown with positions according to human genome build 37 (GRCh37 assembly). Chromosome 23 is the X chromosome. The darker grey and lighter grey dotted horizontal lines indicate genome-wide significance (P = 5 × 10−8) and nominal significance (P = 1 × 10−6), respectively. SNPs in dark purple indicate the lead independent nominally significant SNPs, and any SNPs in linkage disequilibrium with them. Females: 130,471 cases, 159,521 controls. Males: 64,805 cases, 132,185 controls.
