Fig. 4: Crystal structure of the GV37 TCR in complex with HLA-C*12:02-KF9. | Nature Communications

Fig. 4: Crystal structure of the GV37 TCR in complex with HLA-C*12:02-KF9.

From: Molecular basis of potent antiviral HLA-C-restricted CD8+ T cell response to an immunodominant SARS-CoV-2 nucleocapsid epitope

Fig. 4: Crystal structure of the GV37 TCR in complex with HLA-C*12:02-KF9.

a Overview of the GV37 TCR-HLA-C*12:02-KF9 structure. HLA-C*12:02 is presented as a blue cartoon, the KF9 peptide as pink sticks, GV37 TCRα in pale pink, and the TCRβ in the beige cartoon. The CDR1α, CDR2α, and CDR3α loops are coloured in teal, chartreuse, and purple, respectively, while the CDR1β, CRD2β, CDR3β loops are coloured in red, orange, yellow, respectively. b GV37 TCR footprint on the surface of HLA-C*12:02 (white) and KF9 peptide (grey) colour-coded accordingly to the TCR segment involved in the interaction. c-e Cartoon representation of the GV37 TCR interacting with the KF9 peptide (pink stick), coloured as per panel (a), with yellow dashed lines representing contacts <4 Å, and e the black dashed line represents the unique contact of the CDR3β loop with the peptide.

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