Table 4 GV37 TCR contacts with HLA-C*12:02 and the KF9 peptide
TCR segment | TCR residues | HLA-C*12:02 residue | Bond type |
|---|---|---|---|
CDR1α | Thr25 | Arg62 | VdW |
CDR1α | Asp26 | Arg62 | VdW |
CDR1α | Ser28-Oγ | Thr163-Oγ1 | VdW, HB |
CDR1α | Thr30 | Gln155, Ala158 | VdW |
CDR1α | Tyr31-OH | Glu154-Oε1, Gln155 | VdW, HB |
CDR2α | Phe50 | Glu154, Ala158 | VdW |
CDR3α | Glu93 | Gln155 | VdW |
CDR3α | Gly94-N-O | Gln155-Oε1 | VdW, HB |
CDR3α | Thr96 | Arg69 | VdW |
CDR3α | Pro97 | Arg69 | VdW |
FWβ | Tyr48 | Arg69 | VdW |
CDR2β | Glu52-Oε1 | Arg79-Nη1 | VdW, SB |
CDR2β | Ala53 | Val76, Arg79 | VdW |
CDR2β | Gln54 | Gln72 | VdW |
FWβ | Leu55 | Arg69, Gln72, Ala73 | VdW |
FWβ | Asp56-Oδ2 | Arg69-Nε-Nη2, Gln65-Nε2 | VdW, HB, SB |
FWβ | Ser58-Oγ | Gln65-Nε2 | HB |
CDR3β | Leu96 | Ala149 | VdW |
CDR3β | Ala97 | Ala150 | VdW |
CDR3β | Ala100 | Ala150, Gln155 | VdW |
CDR3β | Gly101-O | Arg151-Nε | VdW, HB |
CDR3β | Gly102 | Arg151 | VdW |
CDR3β | Val103 | Ala149 | VdW |
TCR segment | TCR residues | KF9 residue | Bond type |
CDR1α | Asp26-Oδ1 | Lys1-Nζ | VdW, SB |
CDR1α | Ser28-Oγ | Lys1-Nζ | VdW, HB |
CDR3α | Glu93-O-Oε1 | Asn4-Nδ2 | VdW, HB |
CDR3α | Gly94 | Val5 | VdW |
CDR3α | Asn95-N-Nδ2 | Val5-O, Thr6-O, Gln7 | VdW, HB |
CDR3α | Thr96 | Asn4 | VdW |
CDR2β | Gln50-Ne2-Oε1 | Gln7-Oε1, Ala8 | VdW, HB |
CDR3β | Ala97 | Gln7 | VdW* |
