Fig. 6: Pol II TL interaction landscape reveals functional dependency of proximal residues.
From: Widespread epistasis shapes RNA polymerase II active site function and evolution
Specific epistatic interactions observed between hydrophobic residues A1076 and L1101 (a), and M1079 and G1097 are shown as heatmaps (b). The x-axis of both heatmaps are 20 substitutions ordered by predicted phenotypic classes and color coded accordingly. The probe mutants are along the y-axis. c The epistatic interactions we identified between A1076 and L1101, as well as M1079 and G1097, are shown on the five-helix bundle of Pol II active site (PDB: 5C4X).
