Fig. 2: Experimental validation of SSs.
From: Super-silencers are crucial for development and carcinogenesis in B cells
a Elements tested in the experiments, accompanied by the genomic and epigenetic profiles of the regions hosting these elements in normal and cancer genomes. The numbers in the track of “DLBCL SE” and “CLL SE” are the numbers of patients having the corresponding SEs out of all patients. b Luciferase activities of the tested SSs in GM12878 and K562. Data are presented as the median ± SD (n = 9 for controls, and n = 3 for SSctrl1 … SSctrl3 and SS1… SS4, i.e., the sequences located within the SS). All these samples are biological replicates. P values were determined against control elements by two-sided t tests without adjustment. Source data are provided in Supplementary Data 3.
