Fig. 7: Enrichment of SSs in TAD-shores.
From: Super-silencers are crucial for development and carcinogenesis in B cells
a Distribution of REs in different TAD sections (boundaries, shores, and centers). The pi chart presents the distribution of SSs in TADs. “SS comp” and “SE comp” represent SS and SE components, respectively, throughout this figure. b Enrichment of silencers and enhancers in SS-counterpart-TAD-shores. The schematic shows two neighboring TADs. The Shore2 is the counterpart-TAD-shore of the Shore1, and vice versa. Each row in this heatmap represent a TAD boundary. Enrichment fold is calculated through comparing with the whole genome. c Enrichment of enhancers in the SS-counterpart-TAD-shores. The values above bars are the significance level as compared to all TAD-shores. CTCF-TAD-shores have no significant preference for enhancers. Data are presented as the median±SEM. P values (\(\,*\ast P < {10}^{-10}\)) were determined against all TAD boundaries in GM12878 (n = 6240 as documented in the Peakachu31) using two-sided Wilcoxon rank sum tests without adjustment. d Enrichment of disease-associated mutations in different RE types across TAD sections. Pie charts are the distribution of mutations in SS components. “BK” is DNase-seq peaks randomly selected in other cell types. P values (\(\,*\ast P < {10}^{-10}\)) were determined against “BK” using one-sided binomial tests without adjustment.
