Table 2 Scalable synthesis of six non-canonical amino acids at 10-gram scale

From: Modular multi-enzyme cascades enable green and sustainable synthesis of non-canonical amino acids from glycerol

Entry

ncAA

Yield (g L-1)

Isolated yield (%)a

1

(S-allyl-l-cysteine) 3a

9.50

68.4

2

(S-phenyl-l-cysteine) 3b

11.66

77.7

3

(S-carboxymethyl-l-cysteine) 3e

9.21

65.7

4

(S-4-(trifluoromethyl)-thiophenol-l-cysteine) 3j

14.80

74.6

5

(S-triphenylmethyl-l-cysteine) 3n

14.07

54.6

6

(Se-phenyl-l-cysteine) 3r

11.45

67.2

  1. aIsolated yields were determined according to the weight of the purified ncAAs and the theoretical yield. Data are from one independent experiment. Source data are provided as a Source Data file.
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