Fig. 4: Exploration of the effects of MOF NPs on ADSCs programmed by sequencing. | Nature Communications

Fig. 4: Exploration of the effects of MOF NPs on ADSCs programmed by sequencing.

From: Injectable therapeutic system incorporating neurogenesis-programmed stem cells concomitantly promoting muscle regeneration treats stress urinary incontinence

Fig. 4: Exploration of the effects of MOF NPs on ADSCs programmed by sequencing.The alternative text for this image may have been generated using AI.

A Heat map analysis of differential genes for two-by-two comparisons of ADSCs clusters in the untreated group (normal), ZIF-8/PEG200 NPs treated group (ZIF-8/PEG200) and the ZIF-8/PEG200@Mg NPs treated group (ZIF-8/PEG200@Mg). B Up-regulated pathways in GO and KEGG enrichment analysis after mRNA sequencing between normal and ZIF-8/PEG200 group. C Up-regulated pathways in GO and KEGG enrichment analysis after mRNA sequencing between normal and ZIF-8/PEG200@Mg group. D Up-regulated pathways in GO and KEGG enrichment analysis after mRNA sequencing between ZIF-8/PEG200 and ZIF-8/PEG200@Mg group. E Expression of genes related to extracellular matrix, nervous system and actin of normal, ZIF-8/PEG200 and ZIF-8/PEG200@Mg group via qRT-PCR tests (n  =  3 independent samples). F Representative WB images of ADSCs after treatment of MOF NPs for 3 days. Data are expressed as the mean ± SD. All error bars represent SD. p values calculated using one-tailed unpaired t-test. ns, not significant (p > 0.05). Source data are provided as a Source Data file.

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