Fig. 8: Graphical summary.

In mOLs, Tfii-i binds REs of the key myelination genes, Sox10 and Mbp. Conditional deletion of Gtf2i from mOLs alters CNS myelin sheath structure and composition, resulting in enhanced signal conduction and improved motor coordination. Created with BioRender. Rokach, M. (2025) https://BioRender.com/o51w712.