Fig. 1: Discovery of Debio 1453. | Nature Communications

Fig. 1: Discovery of Debio 1453.

From: The bactericidal FabI inhibitor Debio 1453 clears antibiotic-resistant Neisseria gonorrhoeae infection in vivo

Fig. 1

a Afabicin desphosphono (Debio 1452) with structural characteristics governing FabI inhibition. b Representative key compounds in lead optimisation for Neisseria gonorrhoeae FabI (NgFabI). N. gonorrhoeae minimum inhibitory concentration (MIC)50 values were determined for a screening panel of 14 isolates. IC, inhibitory concentration. Source data are provided as a Source Data file.

Back to article page