Fig. 6: Plasma exposure of Debio 1453 dosed as Debio 1453 P in a Neisseria gonorrhoeae murine vaginal infection model. | Nature Communications

Fig. 6: Plasma exposure of Debio 1453 dosed as Debio 1453 P in a Neisseria gonorrhoeae murine vaginal infection model.

From: The bactericidal FabI inhibitor Debio 1453 clears antibiotic-resistant Neisseria gonorrhoeae infection in vivo

Fig. 6

Total (black) and free (blue, accounting for mouse plasma protein binding of 93.7%) Debio 1453 concentrations are the mean from three animals per timepoint, with standard deviation. Error bars below zero cannot be displayed due to the logarithmic scale for the x-axis. The lower limit for quantification of total Debio 1453 was 10 ng/mL. The minimum inhibitory concentration (MIC) range for Debio 1453 is highlighted in grey, and the MIC inhibiting 90% of N. gonorrhoeae isolates (MIC90) is represented by the grey dotted line. Pharmacokinetic parameters were determined using Phoenix WinNonlin by non-compartmental analysis. The area under the curve (AUC)last is for total Debio 1453. Cmax maximum concentration, tmax time taken to reach Cmax, t1/2 half-life. Source data are provided as a Source Data file.

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