Fig. 6: Scope of para-amination of N-arylhydroxylamines.
From: Metal-free para-selective C-H amination and azidation of N-arylhydroxylamines
Method B: Step 1: 1 (0.20 mmol, 1.0 equiv.), 77 (2.0 mmol, 10.0 equiv.), FSIT (0.30 mmol, 1.5 equiv.), Na2CO3 (0.40 mmol, 2.0 equiv.) in 4 ml of MeCN/1,4-Dioxane (3/1) at -20 oC for 3 h. Step 2: Compounds 78-89 in 5 ml of THF/HCl (2.5/2.5) at 25 oC for 4 h, followed by treatment of 1 mol/l of KOH solution after removal of solvent. All yields were determined by the isolated products. FSIT fluorosulfuryl imidazolium triflate.
