Fig. 9: Grams-scale reaction and synthetic applications of the para-aminated products.
From: Metal-free para-selective C-H amination and azidation of N-arylhydroxylamines
Reaction conditions: a Phenylboronic acid, Pd(OAc)2, Xphos, K3PO4, THF, N2, 55 oC, 12 h. b tBuONa, CH3I, DMF, 4 h. c PhI(OAc)2, MeOH, 0 oC, 5 min. d Hydrazine hydrate, 150 oC, 12 h. e Isothiocyanate, THF, 30 oC, 12 h. FSIT fluorosulfuryl imidazolium triflate.
