Fig. 2: Validation of the TNBC epigenetic signature. | Nature Communications

Fig. 2: Validation of the TNBC epigenetic signature.

From: A histone-centric multi-omics study shows that increased H3K4 methylation sustains triple-negative breast cancer phenotypes

Fig. 2

a Volcano plots displaying histone PTM changes versus P values in TN compared to LuA tumors in Cohort 1 (22 LuA, 56 TN), Cohort 2 (15 LuA, 16 TN), and in a subset of laser microdissected (LMD) samples (4 LuA, 12 TN). The horizontal line represents the threshold of statistical significance (p < 0.05 by two-tailed limma moderated t-test). Unmodified peptides are not labeled. The symbol “|” indicates that the modification is present on only one of the indicated residues. b Heatmap display of histone PTM levels in MDA-MB-231FUCCI cells, sorted in G2/M phase and normalized to unsorted cells. *: Significant changes in G2/M-sorted cells versus unsorted cells (p-value < 0.05 by two-tailed paired Student’s t test). Exact p-values are reported in the Source Data file. Grey: not detected.

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