Fig. 7: Induced-behavioral changes of impaired forelimb after CC7 transfer.

Representative image of induced movements including the flexion and extension of elbow (a, b), wrist, fingers (c, d) and finger abduction (e). f Corresponding forelimb movement trajectory with the position of shoulder (S), elbow (E), wrist (W), metacarpophalangeal joint (M), fingertips (F) marked. g The maximum angle changes of induced movements when different μLEDs illuminated middle trunk (transferred C7 nerve). h The number of mice that successfully elicited wrist extension or wrist flexion when illuminating middle trunks with MOSD II as a percentage of the total number of mice in different groups. i, j The maximum angle changes of induced movements when different μLEDs illuminated upper trunk (i) and lower trunk (j). k The number of mice that successfully elicited finger abduction when illuminating lower trunk with MOSD II as a percentage of the total number of mice in different groups. The boxplots in g, i, and j show the median (center line), the 3rd and 1st quartiles (upper and lower bounds of the box, respectively). The whiskers represent the maximum and minimum values, respectively. n = 7 for control group, n = 5 for TBI 12w group, n = 7 for TBI + CC7 4w group, n = 9 for TBI + CC7 8w group, n = 11 for TBI + CC7 12w group in (g–k). *P < 0.05, **P < 0.01, ***P < 0.001, one-way ANOVA and multiple comparison tests with Dunnett’s correct in (g–k).