Fig. 4: Identification of genetically vulnerable brain cell types for Parkinson’s disease across multiple analysis granularities.
From: Disentangling associations between complex traits and cell types with seismic
Cell type-trait associations with a Parkinson’s disease GWAS study31 using cell type characterizations at different granularities from Saunders et al.30. Specifically, cells are partitioned into five different resolutions with increasingly more specific cell type characterizations, the broadest of which is subclass labels (top), to the most specific, which is brain region + fine clusters (bottom). Points represent individual cell types, colored by the neuron type (the most vulnerable dopaminergic neurons, other neurons, or non-neurons). Vertical dashed lines indicate FDR thresholds (0.01 and 0.05). Any cell types with FDR < 0.01 are labeled, except for the subclass and brain region + class granularities, where cell types with FDR < 0.05 are labeled.
