Fig. 1: Schematic of steps to build the SE-GPS to assess side effect risk.
From: Development of a genetic priority score to predict drug side effects using human genetic evidence
A workflow of the data sources and steps to construct the SE-GPS and SE-GPS-DOE as outlined in this analysis. The SE-GPS and SE-GPS-DOE were created in the Open Target dataset (discovery), validated in OnSIDES and then generated for 19,422 genes and 502 phecodeX integers, for which 15,139 genes linked to 499 phenotypes had support from at least one genetic feature and directional evidence (n = 146,011). SE side effect, OT Open Targets, SE-GPS side effect genetic priority score, SE-GPS-DOE side effect genetic priority score with direction of effect.
