Fig. 5: EP2 in Schwann cells blockade abates hindpaw mechanical allodynia (allodynia) but does not delay pain resolution. | Nature Communications

Fig. 5: EP2 in Schwann cells blockade abates hindpaw mechanical allodynia (allodynia) but does not delay pain resolution.

From: Targeting prostaglandin E2 receptor 2 in Schwann cells inhibits inflammatory pain but not inflammation

Fig. 5: EP2 in Schwann cells blockade abates hindpaw mechanical allodynia (allodynia) but does not delay pain resolution.The alternative text for this image may have been generated using AI.

a–c Allodynia, paw thickness and myeloperoxidase (MPO) activity assay after complete Freund’s adjuvant (CFA) or vehicle (Veh) in C57BL/6 J mice treated for 6 consecutive days with diclofenac (25 mg/kg, i.p.), PF-04448948 (PF, 10 mg/kg, i.g.) or Veh (n = 8 mice/group). d–i allodynia, paw thickness and MPO activity assay after CFA or Veh in P1p-Cre or Control mice infected with AAV for selective silencing of d–f, EP2 (-Ptger2) (Plp-Ptger2) or g–i, AKAP150 (Plp-Akap150) (n = 8 mice/group). Data are mean ± s.e.m. a, b, d, e, g, h, 2-way or c, f, i, 1-way ANOVA, Bonferroni correction. *P < 0.05, ***P < 0.001, ****P < 0.0001 vs. Veh, Control/Veh †P < 0.05, ††P < 0.01, ††††P < 0.0001 vs. CFA/Veh, Control/CFA, §§P < 0.01, §§§§P < 0.0001 vs. CFA/diclofenac. Source data are provided as a Source Data file.

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