Fig. 6: Hypothesized mechanism of action of prostaglandins. | Nature Communications

Fig. 6: Hypothesized mechanism of action of prostaglandins.

From: Targeting prostaglandin E2 receptor 2 in Schwann cells inhibits inflammatory pain but not inflammation

Fig. 6: Hypothesized mechanism of action of prostaglandins.The alternative text for this image may have been generated using AI.

Prostaglandins (PGs) released during inflammation promote inflammation and pain by distinct mechanisms. a PGs cause inflammation by an EP2-independent inflammatory process, which is characterized by edema, leukocyte infiltration and release of MPO. b PGs cause pain by activating EP2 on SCs. EP2 generates cAMP, leading to AKAP79-associated activation of PKA in plasma membrane-delimited nanodomains. PKA phosphorylates and activates TRPA1 in SCs, which elicits a calcium-dependent release of reactive oxygen species (H2O2). H2O2 targets TRPA1 on adjacent nociceptors, which results in sustained hypersensitivity to mechanical stimuli.

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