Fig. 1: MIND connectivity in relation to clinical status.

A Effect sizes (Cohen’s d) computed between SSD and HC MIND edges (left) and degrees (middle), where blue indicates a significant reduction of edge and degree in SSD, yellow and red indicate a significant increase, and black indicates no significant differences. Spatial 3D representation of significantly different edges and degrees in SSD compared to HC (right). Supplementary data are provided as a Source Data file. B Effect sizes of MIND edges and degrees stratified by general psychopathology, cognition, and symptomatology. The Cohen’s d of MIND degree for those individuals with SSD whose general psychopathology is more impaired, whose cognition is lower, and whose symptomatology (BPRS, SAPS, and SANS) is equal to or higher than the median of the sample (top row). The Cohen’s d for those whose general psychopathology is less impaired, whose symptomatology is lower, and whose cognition is equal to or higher than the median of the sample is shown in the bottom row. The highlighted regions show those regional degrees that exhibit significant differences from HC after tail area-based false discovery rate (FDR) correction (permutation test, P < 0.05). C Number of significant effect sizes shared across scales for a ‘poor’ and ‘good’ status. BPRS brief psychiatric rating scale, HC healthy control, MIND morphometric inverse divergence, SANS scale for the assessment of negative symptoms, SAPS scale for the assessment of positive symptoms, SSD schizophrenia spectrum disorder.