Fig. 2: Connectivity to disease epicenters.
A Regional MRI brain volumes from subjects with SSD converted into centiles, where blue and red indicate a significant centile reduction and increase, respectively, in SSD compared to the expected regional volume for age- and sex-matched normative individuals (left). Correlation between HC degrees and SSD (middle; two-sided test). Association between HC edges and the structural co-vulnerability to psychosis matrix (right; two-sided test). B Correlation between the corresponding edges to each region and the mean HC (top) and SSD centiles (bottom), where blue and red indicate a negative and positive correlation, respectively. C Connectivity to SSD epicenters stratified by patients with ‘poor’ and ‘good’ general psychopathology, cognition, and symptomatology (BPRS, SAPS, and SANS). The highlighted areas indicate regions where connectivity is significantly correlated with epicenters after tail area-based FDR correction (PBetzel < 0.05; see Supplementary Fig. 12 for Moran significance). Supplementary data are provided as a Source Data file. BPRS brief psychiatric rating scale, HC healthy control, MIND morphometric inverse divergence, SANS scale for the assessment of negative symptoms, SAPS scale for the assessment of positive symptoms, SSD schizophrenia spectrum disorder.
