Fig. 8: Bimagrumab inhibits tumor progression in diabetic mice.
From: Diabetes reshapes pancreatic cancer-associated endothelial niche by accelerating senescence
a Schematic representation of bimagrumab treatment in chow and diabetic KPC tumor-bearing mice (by figdraw.com). b Line graph showing body weight changes in chow (n = 6 mice per group) and diabetic (n = 9 mice per group) KPC tumor-bearing mice treated with IgG, bimagrumab, or bimagrumab+metformin. c Pancreatic tumor samples from chow (n = 6 mice per group) and diabetic (n = 9 mice per group) KPC tumor-bearing mice treated with IgG, bimagrumab, or bimagrumab+metformin. d Bar graph showing tumor volumes in chow (n = 6 mice per group) and diabetic (n = 9 mice per group) KPC tumor-bearing mice treated with IgG, bimagrumab, or bimagrumab+metformin. e Bar graph showing tumor weights in chow (n = 6 mice per group) and diabetic (n = 9 mice per group) KPC tumor-bearing mice treated with IgG, bimagrumab, or bimagrumab+metformin. f Bar graph showing fasting blood glucose changes in diabetic tumor-bearing mice after treatment with 2 doses of IgG, 2 doses of bimagrumab alone, or 2 doses of bimagrumab combined with 7 doses of metformin (n = 9 mice per group). g Representative images of bilateral tibialis anterior muscles from diabetic mice treated with IgG, bimagrumab, or bimagrumab+metformin (n = 9 mice per group). h Bar graph showing the weights of the bilateral tibialis anterior muscles in diabetic mice (n = 9 mice per group). i, j Representative images (i) and quantification (j) of picrosirius red staining (red) in tumors from chow and diabetic KPC tumor-bearing mice treated with IgG or bimagrumab (n = 6 mice per group). k, l Representative images (k) and quantification (l) of α-SMA staining (brown) in tumors from chow and diabetic KPC tumor-bearing mice treated with IgG or bimagrumab (n = 6 mice per group). The bars represent the means ± SDs. P-values were determined by one-way ANOVA (d–f, h) and two-way ANOVA (j, l). The effects of bimagrumab in the chow and diabetic groups were also assessed by two-way ANOVA (d, e). Source data are provided as a Source Data file.
