Table 1 Cox regression for overall survival in primary pancreatic cancer patients from the MSK-IMPACT cohort
From: Diabetes reshapes pancreatic cancer-associated endothelial niche by accelerating senescence
Variables | Univariate Cox regression | Multivariate Cox regression | |||
|---|---|---|---|---|---|
Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-value | ||
Age (years) | 1.005 (0.993−1.018) | 0.388 | |||
Sex | Female | 1.000 | 0.443 | ||
Male | 1.107 (0.854−1.435) | ||||
Diabetes | Without | 1.000 | 0.021 | 1.000 | 0.041 |
With | 1.376 (1.049−1.805) | 1.328 (1.011–1.743) | |||
Autoimmune disease | Without | 1.000 | 0.957 | ||
With | 0.985 (0.573−1.693) | ||||
Coronary artery disease | Without | 1.000 | 0.055 | ||
With | 1.424 (0.993−2.042) | ||||
Hypertension | Without | 1.000 | 0.972 | ||
With | 1.005 (0.775−1.302) | ||||
Pancreatitis | Without | 1.000 | 0.960 | ||
With | 1.010 (0.671−1.521) | ||||
Cancer history | False | 1.000 | 0.397 | ||
True | 0.887 (0.672−1.171) | ||||
Smoking | False | 1.000 | 0.266 | ||
True | 1.160 (0.893−1.505) | ||||
Tumor location | Head | 1.000 | 0.855 | ||
Body/tail | 1.027 (0.768−1.373) | ||||
Neoadjuvant therapy | False | 1.000 | 0.092 | ||
True | 1.570 (0.929−2.652) | ||||
Mutation count | 1.080 (1.032−1.130) | 0.001 | 1.076 (1.027−1.129) | 0.002 | |
Mutation | KRAS | 1.000 | |||
MAPK | 0.772 (0.343−1.738) | 0.532 | |||
Wild type | 0.701 (0.289−1.703) | 0.433 | |||
Tumor purity | 1.568 (0.551–4.465) | 0.400 | |||
