Table 2 Cox regression for overall survival in primary pancreatic cancer patients from the Xijing Hospital cohort
From: Diabetes reshapes pancreatic cancer-associated endothelial niche by accelerating senescence
Variables | Univariate Cox regression | Multivariate Cox regression | |||
|---|---|---|---|---|---|
Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-value | ||
Age (years) | 1.009 (0.989−1.030) | 0.363 | |||
BMI | 0.946 (0.888−1.007) | 0.083 | |||
Sex | Female | 1.000 | 0.288 | ||
Male | 0.823 (0.575−1.179) | ||||
Diabetes | Without | 1.000 | 0.006 | 1.000 | 0.035 |
With | 1.649 (1.156−2.354) | 1.496 (1.030−2.173) | |||
Pancreatitis | Without | 1.000 | 0.488 | ||
With | 1.311 (0.609−2.820) | ||||
Smoking | False | 1.000 | 0.120 | ||
True | 1.346 (0.926−1.957) | ||||
ALT (U/L) | 1.0007 (0.9994−1.0020) | 0.261 | |||
GGT (U/L) | 1.0001 (0.9997−1.0004) | 0.782 | |||
CA199 (U/mL) | 1.0001 (1.0000−1.0001) | 0.005 | 1.0001 (1.0000−1.0001) | 0.009 | |
CEA (ng/mL) | 1.0012 (1.0003−1.0021) | 0.012 | 1.0007 (0.9997−1.0017) | 0.149 | |
Vessel invasion | False | 1.000 | 0.485 | ||
True | 1.169 (0.754−1.813) | ||||
Nerve infiltration | False | 1.000 | 0.317 | ||
True | 1.205 (0.836−1.735) | ||||
Fat tissue invasion | False | 1.000 | 0.805 | ||
True | 1.054 (0.695−1.599) | ||||
Tumor maximum diameter (cm) | 1.124 (1.010−1.252) | 0.033 | 1.133 (1.012–1.268) | 0.031 | |
T stage | T1 | 1.000 | |||
T2 | 1.289 (0.773−2.152) | 0.331 | |||
T3 | 1.701 (0.937–3.090) | 0.081 | |||
Number of metastatic lymph nodes | 1.091 (1.020−1.167) | 0.011 | 1.096 (1.024−1.172) | 0.008 | |
