Fig. 7: Proposed model of how CL controls mitochondrial remodeling. | Nature Communications

Fig. 7: Proposed model of how CL controls mitochondrial remodeling.

From: Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1

Fig. 7: Proposed model of how CL controls mitochondrial remodeling.

a, b OPA1 interactions with randomly distributed CL molecules in membranes trigger the clustering of CL near protein-membrane contact sites and facilitate the remodeling of membranes. a Created in BioRender. Thatavarthy, S. (2025) https://BioRender.com/aoefbz2. c The accumulation of MLCL in membranes restricts the membrane remodeling activity of OPA1 and causes abnormalities in mitochondrial morphology. b, c Created in BioRender. Thatavarthy, S. (2025) https://BioRender.com/jf1oaha.

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