Fig. 2: Vertex-wise sex-by-group interaction effect on cortical thickness. | Nature Communications

Fig. 2: Vertex-wise sex-by-group interaction effect on cortical thickness.

From: Estrogen-related receptor gene expression associates with sex differences in cortical atrophy in isolated REM sleep behavior disorder

Fig. 2

a Clusters showing significant sex-by-group interaction on cortical thickness at a cluster-forming threshold of P < 0.05 and following Monte Carlo permutations. The color bar indicates the statistical significance on a logarithmic scale of P-values (−log10), with positive values (red-yellow scale) indicating the presence of a significantly stronger sex effect in iRBD patients compared to controls. b Average cortical thickness (in mm) across groups in significant clusters, showing significant reduction in cortical thickness in iRBD males (N = 294) compared to iRBD females (N = 49) and controls (131 females, 213 males). The P-values indicate significant differences between groups after one-sided independent two-sample t tests. Box plots display the median (center line), the interquartile range (box; 25th-75th percentiles), and whiskers extending to the most extreme values within 1.5 times the interquartile range from each quartile. Each point represents the mean cortical thickness at cluster peak for each participant. Brain maps were generated using freeview in FreeSurfer. F = females; HC = healthy controls; iRBD = isolated REM sleep behavior disorder; M = males.

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